Psychopharmacology Tips
Carbamazepine discontinuation induced refractoriness?
12/06/04
Carbamazepine discontinuation induced refractoriness?
09:00:53 am, Categories: Mood stabilizers In contrast to lithium, there are no reports of carbamazepine discontinuation induced refractoriness. In fact, tolerance and loss of efficacy, which is associated with long-term use of anticonvulsants, may be decreased with a period of time off the medication with subsequent reresponse with rechallenge.
Ref: - Pazzaglia, P.J. & Post, R.M. (1992) Contingent tolerance and reresponse to carbamazepine: a case study in a patient with trigeminal neuralgia and bipolar disorder. Journal of Neuropsychiatry and Clinical Neurosciences, 4, 76 – 81.
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Psychopharmacology Tips
This blog on Clinical Psychopharmacology is maintained by Dr. Shahul Ameen, M.D., Psychiatrist, St. John's Hospital, Kattappana, Idukki, Kerala, India.
Psychopharmacology Tips is a part of PsyPlexus, a portal for mental health professionals.
This blog is only for educational purpose of psychiatrists and other physicians. The information published in this blog is not intended for use as a substitute for consultation to a licensed health professional. Patients and consumers who visit Psychopharmacology Tips should carefully review the information gathered from the site with a professional healthcare provider.
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