Psychopharmacology Tips
Change in bioavailability of nefazodone with time
12/17/04
Change in bioavailability of nefazodone with time
07:45:05 pm, Categories: Antidepressants Nefazodone undergoes extensive first-pass metabolism, resulting in bioavailability of only 15 – 23%. As is usually the case, first-pass metabolism becomes saturated with chronic dosing, resulting in greater elevations of plasma concentration with dosage increases later in treatment.
Ref: - Dubovsky, S.L. & Thomas, M. (1995) Serotonergic mechanisms and current and future psychiatric practice. Journal of Clinical Psychiatry, 56 (suppl 2): 38-48.
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Psychopharmacology Tips
This blog on Clinical Psychopharmacology is maintained by Dr. Shahul Ameen, M.D., Psychiatrist, St. John's Hospital, Kattappana, Idukki, Kerala, India.
Psychopharmacology Tips is a part of PsyPlexus, a portal for mental health professionals.
This blog is only for educational purpose of psychiatrists and other physicians. The information published in this blog is not intended for use as a substitute for consultation to a licensed health professional. Patients and consumers who visit Psychopharmacology Tips should carefully review the information gathered from the site with a professional healthcare provider.
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