Estrogens in high doses may impair the efficacy of imipramine, whereas low doses may enhance it.
Ref: - Kendall, D.A., Stancel, G.M., Enna, S.J. (1982) The influence of sex hormones on antidepressant-induced alterations in neurotransmitter receptor binding. Journal of Neurosciences, 2: 354-360.
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This blog on Clinical Psychopharmacology is maintained by Dr. Shahul Ameen, M.D., Psychiatrist, St. John's Hospital, Kattappana, Idukki, Kerala, India.
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This blog is only for educational purpose of psychiatrists and other physicians. The information published in this blog is not intended for use as a substitute for consultation to a licensed health professional. Patients and consumers who visit Psychopharmacology Tips should carefully review the information gathered from the site with a professional healthcare provider.