Psychopharmacology Tips
Switching from clozapine to another new-generation antipsychotic
12/29/04
Switching from clozapine to another new-generation antipsychotic
08:47:36 am, Categories: Antipsychotics Cases have been reported in which it was helpful to add the anticholinergic antipsychotic thioridazine for a transitory weaning period before eventually switching a patient from clozapine to another new-generation antipsychotic. This would in theory blunt the proposed increase in cholinergic tone precipitated by the removal of clozapine. However, considering the risk of QTc elevation with thioridazine, a safer alternative might be an anticholinergic antiparkinsonian drug.
Ref: - Osser, D.N. & Sigadel, R.S. (2001) Short-term inpatient pharmacotherapy of schizophrenia. Harvard Review of Psychiatry, 9, 89-104.
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Psychopharmacology Tips
This blog on Clinical Psychopharmacology is maintained by Dr. Shahul Ameen, M.D., Psychiatrist, St. John's Hospital, Kattappana, Idukki, Kerala, India.
Psychopharmacology Tips is a part of PsyPlexus, a portal for mental health professionals.
This blog is only for educational purpose of psychiatrists and other physicians. The information published in this blog is not intended for use as a substitute for consultation to a licensed health professional. Patients and consumers who visit Psychopharmacology Tips should carefully review the information gathered from the site with a professional healthcare provider.
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