Patient variables like older age and female sex have been associated with a poorer response to antidepressant treatment. Illness variables associated with a poor response include unipolar illness, psychotic depression, neurotic premorbid personality, past thyroid dysfunction, familial predisposition to affective disorders, multiple loss events, and a low socioeconomic classification.
Ref: - Souery, D., Lipp, O., Massat, I. & Mendlewicz, J. (2001). The characterization and definition of treatment-resistant mood disorders. In: Treatment-resistant mood disorders, (Eds.) Amsterdam, J.D., Hornig, M. & Nierenberg, A.A. pp 3 – 29, Cambridge: Cambridge University Press.
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This blog on Clinical Psychopharmacology is maintained by Dr. Shahul Ameen, M.D., Psychiatrist, St. John's Hospital, Kattappana, Idukki, Kerala, India.
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