As compared to patients with bipolar I disorder, a lower dose of valproate may be effective in patients with bipolar II disorder. Jacobsen (1993) detected a correlation between the pre-treatment severity of illness and the serum valproate levels required for effective treatment.
Ref: - Jacobsen, F.M. (1993) Low dose valproate: a new treatment for cyclothymia, mild rapid cycling disorders, and premenstrual syndrome. Journal of Clinical Psychiatry, 54, 229–234.
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This blog on Clinical Psychopharmacology is maintained by Dr. Shahul Ameen, M.D., Psychiatrist, St. John's Hospital, Kattappana, Idukki, Kerala, India.
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