Psychopharmacology Tips
Mood destabilization with antidepressants in bipolar disorder
05/20/05
Mood destabilization with antidepressants in bipolar disorder
10:08:02 pm, Categories: Antidepressants Risk factors for mood destabilization with antidepressants in bipolar disorder include the following:
- Genetic risk factors
- Early age at illness onset
- Comorbid substance abuse/dependence
- History of rapid cycling
- Multiple antidepressant trials
- History of antidepressant-induced manias
Assessing for these risk factors before antidepressants are used in bipolar patients may help to reduce the risk for adverse consequences.
Ref: - Goldberg, J.F. (2003) When do antidepressants worsen the course of bipolar disorder? Journal of Psychiatric Practice, 9, 181-194.
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Psychopharmacology Tips
This blog on Clinical Psychopharmacology is maintained by Dr. Shahul Ameen, M.D., Psychiatrist, St. John's Hospital, Kattappana, Idukki, Kerala, India.
Psychopharmacology Tips is a part of PsyPlexus, a portal for mental health professionals.
This blog is only for educational purpose of psychiatrists and other physicians. The information published in this blog is not intended for use as a substitute for consultation to a licensed health professional. Patients and consumers who visit Psychopharmacology Tips should carefully review the information gathered from the site with a professional healthcare provider.
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